Recently GLP-1 treatment has gained popularity as the preferred drug treatments for obesity and related conditions. Participants in clinical trials losing 15-20% of their baseline body weight, according to a January 07 2026 British Journal of Medicine (BMJ) report.
A large proportion of people who go on a GLP-1 based treatment are believed to discontinue use of a GLP-1 receptor agonist within 12 months. This has led to concerns about its efficacy and counters the notion that GLP-1 receptor agonists are a perfect cure for obesity, according to BMJ.
Based on multiple sources and studies, the estimated weight regain after treatment and follow up was 4.8 kg (3.6 to 6.0), 6.0 kg (4.8 to 8.4), and 9.9 kg (8.4 to 10.8) within the first year after stopping treatment. Researchers projected return to baseline weight 1.5 to 1.7 years after cessation of any WMM( weight management medications).
https://www.bmj.com/content/392/bmj-2025-085304
https://herb-sprout.com/2025/12/20/study-details-key-role-of-akkermansia-for-your-health/
https://www.bmj.com/content/392/bmj.r2586#
Herbsprout is a blog and podcast about the health benefits of our gut microbiome, natural remedies, and healthcare innovations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
The contents of this webblog is not intended to be used to treat, cure, mitigate, or diagnose any medical condition. The readers must consult your doctor before you make any changes that could affect your health. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
ADVISORY BOARD:
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
●Jenny Pandol, Co-owner/founder/ COO, Microbiome Learning Center;
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
●Dr. Sabine Hazan, Founder and CEO, Progenabiome and Ventura Clinical Trials;
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
●Naveen Jain, Founder & CEO, Viome
. . . . . . . . . . . . . . . . . . . . . . .
●Hans Parge, ex-Pfizer director;
. . . . . . . . . . . . . . . . . . . . . . . . . . . .
●Chris Kenji Beer, health research/writer
. . . . . . . . . . . . . . . . . .
●Ely Diana, translation/support
HerbSprout.com 