Scientists at University of California, San Diego have developed a new tool called coralME that creates detailed genome-scale computational models of metabolism and gene and protein expression, according to a November 20 2025 report led by Karsten Zengler, PhD, professor of pediatrics at UC San Diego School of Medicine in Genengnews.com.
CoralME highlights how microbes respond to certain nutrients that contribute to a balance or imbalance in the microbiome. The tool studies nutrients favorable versus unfavorable to microbe populations that are beneficial or detrimental to the gut.
Scientists generated 495 ME‑models identifying some of the most common gut species, tested and tracked how different diets affect these gut bacteria. The scientists were able to observe what the microbes were doing in real time.
This could lead to new ways to diagnose and treat conditions like IBD and other diseases.
https://www.genengnews.com/topics/omics/computational-modeling-tool-maps-gut-microbiome-effects-on-health/
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