Hokkaido University’s Faculty of Medicine have shown how our gut microbiome drives a process known as granulopoiesis that replenishes neutrophil counts. Neutrophils are a type of white blood cell that helps the body fight infection.
They tested changes in the blood of mice following treatments such as hematopoietic, stem cell transplants (SCT) or chemotherapy, according to Genetic Engineering and Biotechnology News (November 22, 2022 issue). The mechanism was found to depend on T cell production of IL-17. Low neutrophil counts in the blood or neutropenia happens in leukemia patients, stem cell transplantation or following chemotherapy.
Research was led by Hokkaido University’s Associate Professor Daigo Hashimoto, PhD, and Professor Takanori Teshima, PhD. The potential clinically relevance of this finding can lead to “rapid recovery of neutrophils after SCT and chemotherapy”, says Dr. Hashimoto in Genentech News.
https://www.genengnews.com/news/gut-microbiome-drives-production-of-neutrophils-after-prolonged-chemotherapy/
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